Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

Cell-free DNA (cfDNA) sequencing has demonstrated great potential for early cancer
detection. However, most large-scale studies have focused only on either targeted …

One of the traits of cancer cells is abnormal DNA methylation patterns. The idea that age-
related epigenetic changes may partially explain the increased risk of cancer in the elderly is …

The strong interest shown in the study of the causes of aging in recent decades has
uncovered many mechanisms that could contribute to the rate of aging. These include …

The proportion of patients diagnosed with cancer has been shown to rise with the increasing
aging global population. Advanced age is a major risk factor for morbidity and mortality in …

Simple Summary Breast cancer is a significant health problem affecting millions of women
worldwide, particularly post-menopausal women. Although early detection and treatment …

Biological clock technologies are designed to assess the acceleration of biological age (B-
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …

Abstract Background Circulating tumor DNA (ctDNA) has emerged as a potential diagnostic
and prognostic biomarker in various tumors. However, the role of tumor suppressor genes …

Epigenetics encompasses the changes in gene expression triggered by environmental cues
that occur without altering the underlying DNA sequences. Although epigenetics involves a …