Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

For decades, common chemotherapeutic drugs have been established to trigger apoptosis,
the preferred immunologically “silent” form of cell death. The primary objective of this review …

Pediatric cancers are the driving cause of death for children and adolescents. Due to safety
requirements and considerations, treatment strategies and drugs for pediatric cancers have …

Pyroptosis is a programmed cell death mode discovered in recent years. It is caused by
inflammasomes and the perforation of Gasdermin family proteins, and results in the release …

Purpose Recent scientific reports have revealed a close association between ferroptosis
and the occurrence and development of osteoarthritis (OA). Nevertheless, the precise …

Ethnopharmacological relevance Atherosclerosis (AS) is a common systemic disease with
increasing morbidity and mortality worldwide. Traditional Chinese medicine (TCM) with …

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …

The endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis.
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the …

In 2012, researchers proposed a non-apoptotic, iron-dependent form of cell death caused by
lipid peroxidation called ferroptosis. During the past decade, a comprehensive …