Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …

Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …

Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

The bile acid receptor FXR has emerged as a bona fide drug target for chronic cholestatic
and metabolic liver diseases, ahead of all non-alcoholic fatty liver disease (NAFLD). FXR is …

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic
activity of asparagine synthetase (ASNS). While ASNS and asparagine have been …

Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity.
Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and
has no approved treatment. The hepatic farnesoid X receptor (FXR) is one of the most …

Farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates bile acid
homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR …