The tryptophan and kynurenine pathway is well-known to play an important role in nervous,
endocrine, and immune systems, as well as in the development of inflammatory diseases. It …

The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates
immune cell environmental sensing through its activation by cellular, dietary, and microbial …

The large intestine harbors microorganisms playing unique roles in host physiology. The
beneficial or detrimental outcome of host‐microbiome coexistence depends largely on the …

Tissue‐resident memory T cells (TRM) represent a dedicated layer of localized immune
memory in virtually every organ throughout the human body. By virtue of their long‐term …

The human skin is populated by a diverse pool of memory T cells, which can act rapidly in
response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have …

Type 1 diabetes mellitus (T1DM) arises from the failure of pancreatic β-cells to produce
adequate insulin, usually as a consequence of extensive pancreatic β-cell destruction …

The networks of transcription factors (TFs) that control intestinal-resident memory CD8+ T
(TRM) cells, including multipotency and effector programs, are poorly understood. In this …

Cryptosporidium is a leading cause of diarrheal-related deaths in children, especially in
resource-poor settings. It also targets the immunocompromised, chronically infecting people …

Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and
constitute an integral component of the local defense network against immunological …

Abstract Introduction Resident memory T (T RM) cells are embedded in peripheral tissue
and capable of acting as sentinels that can respond quickly to repeat pathogen exposure as …