Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

COVID-19 in pregnancy: implications for fetal brain development

LL Shook, EL Sullivan, JO Lo, RH Perlis… - Trends in molecular …, 2022 - cell.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
during pregnancy on the developing fetal brain is poorly understood. Other antenatal …

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

MD Rudolph, AM Graham, E Feczko… - Nature …, 2018 - nature.com
Several lines of evidence support the link between maternal inflammation during pregnancy
and increased likelihood of neurodevelopmental and psychiatric disorders in offspring. This …

Immune dysregulation in autism spectrum disorder: what do we know about it?

MA Robinson-Agramonte, E Noris García… - International journal of …, 2022 - mdpi.com
Autism spectrum disorder (ASD) is a group of complex multifactorial neurodevelopmental
disorders characterized by a wide and variable set of neuropsychiatric symptoms, including …

[HTML][HTML] Cytokine research in depression: principles, challenges, and open questions

H Himmerich, O Patsalos, N Lichtblau… - Frontiers in …, 2019 - frontiersin.org
Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk

AP Kępińska, CO Iyegbe, AC Vernon, R Yolken… - Frontiers in …, 2020 - frontiersin.org
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …

[HTML][HTML] Microbiota-immune-brain interactions: A lifespan perspective

A Ratsika, JSC Pereira, CMK Lynch, G Clarke… - Current Opinion in …, 2023 - Elsevier
There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis
and influencing brain and behaviour at critical windows across the lifespan. Mounting …

Neurodevelopmental resilience and susceptibility to maternal immune activation

U Meyer - Trends in neurosciences, 2019 - cell.com
Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is
implicated in various psychiatric and neurological disorders with developmental etiologies …

Cross talk: the microbiota and neurodevelopmental disorders

JR Kelly, C Minuto, JF Cryan, G Clarke… - Frontiers in …, 2017 - frontiersin.org
Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut
microbiota can signal to the brain via the immune system, the vagus nerve or other host …

Maternal inflammation and its ramifications on fetal neurodevelopment

HK Kwon, GB Choi, JR Huh - Trends in immunology, 2022 - cell.com
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …