Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy

L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis

MR Aburto, JF Cryan - Nature Reviews Gastroenterology & Hepatology, 2024 - nature.com
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

LY Hung, KG Margolis - Nature Reviews Gastroenterology & …, 2024 - nature.com
Autism spectrum disorders (ASDs) are recognized as central neurodevelopmental disorders
diagnosed by impairments in social interactions, communication and repetitive behaviours …

Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring

T Wang, B Chen, M Luo, L Xie, M Lu, X Lu, S Zhang… - Microbiome, 2023 - Springer
Background Autism spectrum disorder (ASD) has been associated with intrauterine growth
restriction (IUGR), but the underlying mechanisms are unclear. Results We found that the …

[HTML][HTML] Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of …

E Zahedi, SS Sadr, A Sanaeierad, M Roghani - Biomedicine & …, 2023 - Elsevier
Autism spectrum disorder is characterized by a variety of cellular and molecular
abnormalities which leads to autism-associated behaviors. Besides behavioral defects …

Influence of immune system abnormalities caused by maternal immune activation in the postnatal period

Y Shimizu, H Sakata-Haga, Y Saikawa, T Hatta - Cells, 2023 - mdpi.com
The developmental origins of health and disease (DOHaD) indicate that fetal tissues and
organs in critical and sensitive periods of development are susceptible to structural and …

Existing and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disorders

FC Ross, DE Mayer, A Gupta, CIR Gill, D Del Rio… - Biological …, 2024 - Elsevier
Nutrition and diet quality play key roles in preventing and slowing cognitive decline and
have been linked to multiple brain disorders. This review compiles available evidence from …

Role of maternal immune factors in neuroimmunology of brain development

M Mohebalizadeh, G Babapour… - Molecular …, 2023 - Springer
Inflammation during pregnancy may occur due to various factors. This condition, in which
maternal immune system activation occurs, can affect fetal brain development and be …

The enteric nervous system deficits in autism spectrum disorder

X Wang, R Tang, Z Wei, Y Zhan, J Lu, Z Li - Frontiers in Neuroscience, 2023 - frontiersin.org
Gastrointestinal (GI) disorders are common comorbidities in individuals with autism
spectrum disorder (ASD), and abnormalities in these issues have been found to be closely …

Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both …

E González-Madrid, MA Rangel-Ramírez… - Frontiers in …, 2024 - frontiersin.org
Background The prevalence of autism spectrum disorder (ASD) has significantly risen in the
past three decades, prompting researchers to explore the potential contributions of …