The two major components of the kidney, the collecting system and the nephron, have
different developmental histories. The collecting system arises by the reiterated branching of …

Polarized epithelial cells have a distinctive apical–basal axis of polarity for vectorial
transport of ions and solutes across the epithelium. In contrast, migratory mesenchymal cells …

Classic tissue recombination and in vitro lineage tracing studies suggest that condensed
metanephric mesenchyme (MM) gives rise to nephronic epithelium of the adult kidney …

Changes in transcript levels are assessed by microarray analysis on an individual basis,
essentially resulting in long lists of genes that were found to have significantly changed …

Histone deacetylases (HDACs) regulate fundamental biological processes such as cellular
proliferation, differentiation, and survival via genomic and nongenomic effects. This study …

Within the developing mammalian kidney, several populations of progenitors form the
discrete cellular components of the final organ. Fate mapping experiments revealed the cap …

Reviews and critical articles covering the entire field of normal anatomy (cytology, histology,
cyto-and histochemistry, electron microscopy, macroscopy, experimental morphology and …

Early kidney development in mammals is characterized by reciprocal tissue interaction
between the ureteric bud and the metanephric mesenchyme. The coordinated response to …

Background Research on spatiotemporal gene landscape can provide insights into the
spatial characteristics of human kidney development and facilitate kidney organoid …

The structure of a mammalian kidney is parsed into large collections of polarized nephrons,
and each segment is home to a diverse community of cells that specialize in renal endocrine …