Objective: This clinical practice guideline addresses the diagnosis and treatment of primary
adrenal insufficiency. Participants: The Task Force included a chair, selected by The Clinical …

Background Pneumonia is a common and potentially serious illness. Corticosteroids have
been suggested for the treatment of different types of infection, however their role in the …

The natural history of cirrhosis is characterised by an asymptomatic compensated phase
followed by a decompensated phase, marked by the development of overt clinical signs, the …

Objective To update the 2008 consensus statements for the diagnosis and management of
critical illness-related corticosteroid insufficiency (CIRCI) in adult and pediatric patients …

Background The global burden of sepsis is estimated as 15 to 19 million cases annually,
with a mortality rate approaching 60% in low-income countries. Methods In this retrospective …

Bacterial infections are very common and represent one of the most important reasons of
progression of liver failure, development of liver-related complications, and mortality in …

Context The normal cortisol response 30 or 60 minutes after cosyntropin (ACTH [1–24]) is
considered to be≥ 18 μg/dL (500 nmol/L). This threshold is based on older serum cortisol …

Objective To provide a narrative review of the latest concepts and understanding of the
pathophysiology of critical illness-related corticosteroid insufficiency (CIRCI). Participants A …

Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …

Importance Adjunctive hydrocortisone therapy is suggested by the Surviving Sepsis
Campaign in refractory septic shock only. The efficacy of hydrocortisone in patients with …