Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Apolipoprotein E (APOE) is a lipid transporter produced predominantly by astrocytes in the
brain. The ε4 variant of APOE (APOE4) is the strongest and most common genetic risk factor …

Astrocytes are emerging as key regulators of cognitive function and behavior. This review
highlights some of the latest advances in the understanding of astrocyte roles in different …

The apolipoprotein E ɛ4 allele (APOE4) is universally acknowledged as the most potent
genetic risk factor for Alzheimer's disease (AD). APOE4 promotes the initiation and …

Abstract Background and Purpose Blood–brain barrier (BBB) breakdown is one of the
crucial pathological changes of cerebral ischaemia–reperfusion (I/R) injury. Trilobatin (TLB) …

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of
Alzheimer's disease (AD). Mobilization of transposable elements (TEs) in heterochromatic …

Alzheimer disease (AD) models are based on the notion that abnormal protein aggregation
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …