The chemokine system mediates acute inflammation by driving leukocyte migration to
damaged or infected tissues. However, elevated expression of chemokines and their …

Discernable genetic variation among people and populations has an important role in
infectious disease epidemics, including that of acquired immune deficiency syndrome …

Background: Studies relating certain chemokine and chemokine receptor gene alleles with
the outcome of HIV-1 infection have yielded inconsistent results. Objective: To examine …

The pivotal discovery that two chemokine receptors, CCR5 and CXCR4, serve along with
the T-cell receptor-interacting CD4 molecule as the principal co-receptors for HIV-1 entry …

The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

Transmission of HIV first results in an acute infection, followed by an apparently
asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most …

Susceptibility to HIV infection and AIDS progression is variable among individuals and
populations, and in part genetically determined. Genetic variants of genes encoding HIV co …

The CC chemokine receptor type 5 (CCR5) is a receptor expressed by T cells and
macrophages that serves as a coreceptor for macrophage-tropic HIV-1. Loss of CCR5 is …

Chemokines and chemokine receptors play a crucial role in the trafficking of leukocyte
populations across the body, and are involved in the development of a large variety of …

Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that
serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of …