The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and
extrinsic factors influence signaling along this axis, modulating the function of both the …

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

Aims The aim of this study was to determine the differences and potential mechanistic
rationale for observed adverse drug reactions (ADRs) between four approved PARP …

The increase in temperature due to global warming greatly affects the toxicity produced by
pesticides in the aquatic ecosystem. Studies investigating the effects of such environmental …

Despite the availability of over 30 antiseizure medications (ASMs), there is no “one size fits it
all,” so there is a continuing search for novel ASMs. There are divergent data demonstrating …

The constitutive activity of different serotonin receptors (5-HTRs) toward intracellular
signaling pathways has been proposed to have physiological and pathological importance …

Background Between 30 and 50% of patients with major depressive disorder (MDD) do not
respond sufficiently to antidepressant regimens. The conventional pharmacological …

Importance The cerebral serotonin 4 (5-HT 4) receptor is a promising novel target for
treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT …

Rationale Depression is a mental disorder that affects approximately 280 million people
worldwide. In the search for new treatments for mood disorders, compounds containing …

Concurrent anxiety is frequent in major depressive disorder and a shared
pathophysiological mechanism between anxiety and other depressive symptoms is …