In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

Plasmodium vivax is the most widespread human malaria parasite, in part because it can
form latent liver stages known as hypnozoites after transmission by female anopheline …

Human malaria affects the vast majority of the world's population with the Plasmodium
falciparum species causing the highest rates of morbidity and mortality. With no licensed …

Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver
stages and the disease-causing blood stages of the human malaria parasite Plasmodium …

Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …

Malaria, caused by Plasmodium parasites is a severe disease affecting millions of people
around the world. Plasmodium undergoes obligatory development and replication in the …

Adjuvanted protein vaccines offer high efficacy, yet most potent adjuvants remain
proprietary. Several adjuvant compounds are being developed by the Vaccine Formulation …

The secreted malarial protein, Cell-Traversal protein for Ookinetes and Sporozoites
(CelTOS), is highly conserved among Plasmodium species, and plays a role in the invasion …

Malaria is one of the major causes of a high death rate due to infectious diseases every
year. Despite attempts to eradicate the disease, results have not been very successful. New …

Inflammasome-mediated caspase-1 activation facilitates innate immune control of
Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria …