Retinal pigment epithelium-secretome: A diabetic retinopathy perspective

M Ponnalagu, M Subramani, C Jayadev, R Shetty… - Cytokine, 2017 - Elsevier
Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal
vascular abnormalities and visual impairment. While retinal endothelial pathology is well …

[HTML][HTML] Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes

Q Li, M Wang, X Li, Y Shao - Experimental Gerontology, 2023 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness worldwide and a costly
complication of diabetes mellitus (DM). DR severity is associated with DM duration; thus, DR …

Glucose‐induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs

J Liu, S Chen, S Biswas, N Nagrani, Y Chu… - Physiological …, 2020 - Wiley Online Library
Diabetic complications cause significant morbidity and mortality. Dysfunction of vascular
endothelial cells (ECs), caused by oxidative stress, is a main mechanism of cellular damage …

Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision

F Karamali, S Behtaj, S Babaei-Abraki… - Journal of translational …, 2022 - Springer
Photoreceptors (PRs), as the most abundant and light-sensing cells of the neuroretina, are
responsible for converting light into electrical signals that can be interpreted by the brain. PR …

Unconventional avenues to decelerate diabetic retinopathy

B Takkar, A Sheemar, R Jayasudha, D Soni… - Survey of …, 2022 - Elsevier
Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus
(DM), causing significant visual impairment worldwide. Current gold standards for retarding …

Role of oxidative stress in diabetic retinopathy and the beneficial effects of flavonoids

MS Ola, D Al-Dosari… - Current Pharmaceutical …, 2018 - ingentaconnect.com
Diabetic Retinopathy (DR) is one of the leading causes of decreased vision and blindness in
developed countries. Diabetes-induced metabolic disorder is believed to increase oxidative …

Spermine oxidase: a promising therapeutic target for neurodegeneration in diabetic retinopathy

SP Narayanan, E Shosha, CD Palani - Pharmacological research, 2019 - Elsevier
Diabetic Retinopathy (DR), is a significant public health issue and the leading cause of
blindness in working-aged adults worldwide. The vision loss associated with DR affects …

Protective effects on the retina after ranibizumab treatment in an ischemia model

SC Joachim, M Renner, J Reinhard, C Theiss, C May… - PloS one, 2017 - journals.plos.org
Retinal ischemia is common in eye disorders, like diabetic retinopathy or retinal vascular
occlusion. The goal of this study was to evaluate the potential protective effects of an …

Fewer functional deficits and reduced cell death after ranibizumab treatment in a retinal ischemia model

M Palmhof, S Lohmann, D Schulte, G Stute… - International Journal of …, 2018 - mdpi.com
Retinal ischemia is an important factor in several eye disorders. To investigate the impact of
VEGF inhibitors, as a therapeutic option, we studied these in a retinal ischemia animal …

Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway

YF Zhou, HW Liu, X Yang, CX Li, JS Chen… - International …, 2023 - Springer
Purpose This study investigated the protective effect of probucol on Müller cells exposed to
high glucose conditions and examined potential mechanisms of action. Methods Primary …