Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Early experiments in mice predicted the success of checkpoint blockade immunotherapy in
cancer patients. However, these same animal studies failed to accurately predict many of the …

Dendritic cells (DC) have a critical effect on the outcome of adaptive immune responses
against growing tumors. Whereas it is generally assumed that the presence of …

Obesity is a mounting health concern in the United States and is associated with an
increased risk for developing several cancers, including renal cell carcinoma (RCC) …

Naive T cell responses are eroded with aging. We and others have recently shown that
unimmunized old mice lose≥ 70% of Ag-specific CD8 T cell precursors and that many of the …

Decline in immune function and inflammation concomitantly develop with ageing. Here we
focus on the impact of this inflammatory environment on T cells, and demonstrate that in …

The increased incidence of malignancies in elderly patients living in industrialized countries
has led to both identify the causes that alter the normal homeostatic balance in elderly and …

Increasing evidence has revealed the incidence of cancer augments with aging, which could
be attributed to a multitude of age-associated changes including the dysregulation of the …

Dendritic cells (DCs) are actively used as cellular adjuvant in cancer immunotherapy.
However, although DC immunotherapies primarily target the elderly population, little is …

Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence
that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to …