Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

G Caruso, SA Torrisi, MP Mogavero, W Currenti… - Pharmacology & …, 2022 - Elsevier
Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Role of SARS-CoV-2 spike-protein-induced activation of microglia and mast cells in the pathogenesis of neuro-COVID

TC Theoharides, D Kempuraj - Cells, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). About 45% of COVID-19 patients experience several symptoms a …

[HTML][HTML] Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota

R García-Villalba, FA Tomás-Barberán… - Molecular Aspects of …, 2023 - Elsevier
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but
extensively metabolized by the human gut microbiota to produce different urolithins (Uros) …

From cocoa to chocolate: Effect of processing on flavanols and methylxanthines and their mechanisms of action

L Goya, JE Kongor, S de Pascual-Teresa - International Journal of …, 2022 - mdpi.com
Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …

Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

B Zimmerman, B Rypma, G Gratton… - …, 2021 - Wiley Online Library
The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Flavonoids: Potential candidates for the treatment of neurodegenerative disorders

S Devi, V Kumar, SK Singh, AK Dubey, JJ Kim - Biomedicines, 2021 - mdpi.com
Neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD),
Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are the most concerning …

Nutrition strategies promoting healthy aging: From improvement of cardiovascular and brain health to prevention of age-associated diseases

M Fekete, Z Szarvas, V Fazekas-Pongor, A Feher… - Nutrients, 2022 - mdpi.com
Background: An increasing number of studies suggest that diet plays an important role in
regulating aging processes and modulates the development of the most important age …

Clinical evidence of the benefits of phytonutrients in human healthcare

N Monjotin, MJ Amiot, J Fleurentin, JM Morel, S Raynal - Nutrients, 2022 - mdpi.com
Phytonutrients comprise many different chemicals, including carotenoids, indoles,
glucosinolates, organosulfur compounds, phytosterols, polyphenols, and saponins. This …

The health effects of chocolate and cocoa: A systematic review

TYC Tan, XY Lim, JHH Yeo, SWH Lee, NM Lai - Nutrients, 2021 - mdpi.com
Chocolate has a history of human consumption tracing back to 400 AD and is rich in
polyphenols such as catechins, anthocyanidins, and pro anthocyanidins. As chocolate and …