[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] Inhalable neutralizing antibodies–promising approach to combating respiratory viral infections

MYT Chow, HW Pan, HC Seow, JKW Lam - Trends in pharmacological …, 2023 - cell.com
Monoclonal antibodies represent an exciting class of therapeutics against respiratory viral
infections. Notwithstanding their specificity and affinity, the conventional parenteral …

[HTML][HTML] The latest Omicron BA. 4 and BA. 5 lineages are frowning toward COVID‐19 preventive measures: a threat to global public health

MR Islam, M Shahriar, MA Bhuiyan - Health science reports, 2022 - ncbi.nlm.nih.gov
1. BACKGROUND A cluster of pneumonia cases was reported by the Wuhan Municipal
Health Commission, China, Hubei Province, resulting in the identification of a novel …

Respiratory delivery of passive immunotherapies for SARS-CoV-2 prophylaxis and therapy

D Focosi, F Maggi - Human Vaccines & Immunotherapeutics, 2023 - Taylor & Francis
Convalescent plasma has been extensively tested during the COVID-19 pandemic as a
transfusion product. Similarly, monoclonal antibodies have been largely administered either …

[HTML][HTML] Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers

T Imsuwansri, T Jongthitinon, N Pojdoung… - Scientific Reports, 2023 - nature.com
An HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-
CoV-2 (nasal antibody spray or NAS) was developed to strengthen COVID-19 management …

Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation

HC Seow, JP Cai, HW Pan, C Luo, K Wen… - … Clinics and Research, 2023 - journals.lww.com
Neutralising monoclonal antibody (mAb) is an important weapon in our arsenal for
combating respiratory viral infections. However, the effectiveness of neutralising mAb has …

Multicolor-Assay-on-a-Chip Processed by Robotic Operation (MACpro) with Improved Diagnostic Accuracy for Field-Deployable Detection

B Liu, Y Cheng, X Pan, W Yang, X Li, L Wang… - Analytical …, 2024 - ACS Publications
The ability to deploy decentralized laboratories with autonomous and reliable disease
diagnosis holds the potential to deliver accessible healthcare services for public safety …

[HTML][HTML] Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron

X Zhang, F Luo, H Zhang, H Guo, J Zhou, T Li, S Chen… - JCI insight, 2024 - ncbi.nlm.nih.gov
BACKGROUND As Omicron is prompted to replicate in the upper airway, neutralizing
antibodies (NAbs) delivered through inhalation might inhibit early-stage infection in the …

A bivalent form of a RBD-specific synthetic antibody effectively neutralizes SARS-CoV-2 variants

DG Kim, U Kim, IH Park, B Ryu, Y Yoo, JS Cha… - Antiviral Research, 2023 - Elsevier
Abstract Coronavirus Disease 2019 (COVID-19) pandemic is severely impacting the world,
and tremendous efforts have been made to deal with it. Despite many advances in vaccines …

[HTML][HTML] Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19

X Li, P Peng, H Deng, Q Yang, S Chen, B Li… - … and Targeted Therapy, 2023 - nature.com
Previously, we identified an antibody combination A8G6 that showed promising efficacy in
COVID-19 animal models and favorable safety profile in preclinical models as well as in a …