Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

The strongest known genetic risk factor for the development of late-onset Alzheimer disease
is inheritance of the apolipoprotein (apo) E4 (ε4 allele) although the mechanisms underlying …

Lipoprotein metabolism in brain has not yet been fully elucidated, although there are a few
reports concerning lipids in the brain and lipoproteins and apolipoproteins in the …

Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

Composition of central nervous system lipoproteins affects the metabolism of lipoprotein
constituents within the brain. The ε4 allele of apolipoprotein E (apoE) is a risk factor for …

We propose the hypothesis that small high‐density lipoprotein (HDL) particles reduce the
risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting …

We investigated the lipoprotein distribution and composition in cerebrospinal fluid (CSF) in a
group of patients with Alzheimer's disease (AD) or affected by other types of dementia in …

Abstract I. Introduction II. Pathology of AD A. Cerebrovascular Pathology and the BBB in AD
B. Changes in Vascular Enzymes and Proteins in AD C. Leakage of Endogenous Serum …

Imbalances of oxidative homeostasis and lipid peroxidation have been revealed as
important factors involved in neurodegenerative disorders such as Alzheimer's disease. The …

The ε4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD). ApoE,
which is important for lipid metabolism, is also a major constituent of cerebrospinal fluid …