Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs–a review
OO Ajani, KT Iyaye, OT Ademosun - RSC advances, 2022 - pubs.rsc.org
Quinoline, which consists of benzene fused with N-heterocyclic pyridine, has received
considerable attention as a core template in drug design because of its broad spectrum of …
considerable attention as a core template in drug design because of its broad spectrum of …
Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …
Recent developments in antimalarial activities of 4-aminoquinoline derivatives
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
Recent advances in functionalized quinoline scaffolds and hybrids—Exceptional pharmacophore in therapeutic medicine
Quinoline is one of the most common nitrogen-containing heterocycles owing to its
fascinating pharmacological properties and synthetic value in organic and pharmaceutical …
fascinating pharmacological properties and synthetic value in organic and pharmaceutical …
Recent developments in the synthesis of hybrid antimalarial drug discovery
BP Raiguru, J Panda, S Mohapatra, S Nayak - Bioorganic Chemistry, 2023 - Elsevier
In this 21 st century, Malaria remains a global burden and causes massive economic trouble
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
[HTML][HTML] Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4 (2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study
A diverse set of tetrahydrobenzofuran-4 (2H)-one derivative 4 (ao) were synthesized using a
one-pot treatment of dimedone, 3-(1H-imidazol-1-yl) benzaldehyde, and different phenacyl …
one-pot treatment of dimedone, 3-(1H-imidazol-1-yl) benzaldehyde, and different phenacyl …
Synthesis of Novel Benzenesulfonamide-Bearing Functionalized Imidazole Derivatives as Novel Candidates Targeting Multidrug-Resistant Mycobacterium abscessus …
B Balandis, P Kavaliauskas, B Grybaitė, V Petraitis… - Microorganisms, 2023 - mdpi.com
Infections caused by drug-resistant (DR) Mycobacterium abscessus (M. abscessus) complex
(MAC) are an important public health concern, particularly when affecting individuals with …
(MAC) are an important public health concern, particularly when affecting individuals with …
[HTML][HTML] 2-Azidobenzaldehyde-Based [4+ 2] Annulation for the Synthesis of Quinoline Derivatives
Quinoline is a privileged heterocyclic ring which can be found in many drug molecules and
bioactive compounds. The development of synthetic methods for making quinoline …
bioactive compounds. The development of synthetic methods for making quinoline …
Recent pharmacological insights about imidazole hybrids: a comprehensive review
In this review, we evaluated the biological activities of hybrid molecules incorporating
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …