Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …
Medicinal chemistry insights into antiviral peptidomimetics
D Ding, S Xu, EF da Silva-Júnior, X Liu, P Zhan - Drug Discovery Today, 2023 - Elsevier
Highlights•Peptidomimetics are an important class of compounds with improved binding
affinities, enhanced metabolic stability, and favorable bioavailability.•Extensive medicinal …
affinities, enhanced metabolic stability, and favorable bioavailability.•Extensive medicinal …
Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
Although the accessory proteins are considered non-essential for coronavirus replication,
accumulating evidences demonstrate they are critical to virus-host interaction and …
accumulating evidences demonstrate they are critical to virus-host interaction and …
Novel investigational anti-SARS-CoV-2 agent ensitrelvir “S-217622”: a very promising potential universal broad-spectrum antiviral at the therapeutic frontline of …
Lately, nitrogenous heterocyclic antivirals, such as nucleoside-like compounds, oxadiazoles,
thiadiazoles, triazoles, quinolines, and isoquinolines, topped the therapeutic scene as …
thiadiazoles, triazoles, quinolines, and isoquinolines, topped the therapeutic scene as …
Efficacious preclinical repurposing of the nucleoside analogue didanosine against COVID-19 polymerase and exonuclease
AM Rabie - ACS omega, 2022 - ACS Publications
Analogues and derivatives of natural nucleosides/nucleotides are considered among the
most successful bioactive species of drug-like compounds in modern medicinal chemistry …
most successful bioactive species of drug-like compounds in modern medicinal chemistry …
Promising experimental anti-SARS-CoV-2 agent “SLL-0197800”: the prospective universal inhibitory properties against the coming versions of the coronavirus
Isoquinoline derivatives having some nucleosidic structural features are considered as
candidate choices for effective remediation of the different severe acute respiratory …
candidate choices for effective remediation of the different severe acute respiratory …
Forodesine and Riboprine Exhibit Strong Anti-SARS-CoV-2 Repurposing Potential: In Silico and In Vitro Studies
Lately, nucleos (t) ide antivirals topped the scene as top options for the treatment of
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …
Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases
The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional
interactions between the host and the pathogen. Here, we repurposed antiviral drugs …
interactions between the host and the pathogen. Here, we repurposed antiviral drugs …
Potent dual polymerase/exonuclease inhibitory activities of antioxidant aminothiadiazoles against the COVID-19 omicron virus: a promising in silico/in vitro …
Recently, natural and synthetic nitrogenous heterocyclic antivirals topped the scene as first
choices for the treatment of the severe acute respiratory syndrome coronavirus 2 (SARS …
choices for the treatment of the severe acute respiratory syndrome coronavirus 2 (SARS …