[HTML][HTML] RASA2 ablation in T cells boosts antigen sensitivity and long-term function
The efficacy of adoptive T cell therapies for cancer treatment can be limited by suppressive
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …
signals from both extrinsic factors and intrinsic inhibitory checkpoints,. Targeted gene editing …
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection
Abstract γδ T cells are potent anticancer effectors with the potential to target tumours
broadly, independent of patient-specific neoantigens or human leukocyte antigen …
broadly, independent of patient-specific neoantigens or human leukocyte antigen …
Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/IL …
Abstract Background The interleukin (IL)-36 cytokines are a sub-family of the IL-1 family
which are becoming increasingly implicated in the pathogenesis of inflammatory diseases …
which are becoming increasingly implicated in the pathogenesis of inflammatory diseases …
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer
Metabolic reprogramming is key for cancer development, yet the mechanism that sustains
triple-negative breast cancer (TNBC) cell growth despite deficient pyruvate kinase M2 …
triple-negative breast cancer (TNBC) cell growth despite deficient pyruvate kinase M2 …
[HTML][HTML] Approaches in Gene Coexpression Analysis in Eukaryotes
Simple Summary Genes whose expression levels rise and fall similarly in a large set of
samples, may be considered coexpressed. Gene coexpression analysis refers to the en …
samples, may be considered coexpressed. Gene coexpression analysis refers to the en …
[HTML][HTML] Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system
H Yoon, SG Park, HJ Kim, HR Shin, KT Kim… - … & Molecular Medicine, 2023 - nature.com
Although the normal physiological level of oxidative stress is beneficial for maintaining bone
homeostasis, imbalance between reactive oxygen species (ROS) production and …
homeostasis, imbalance between reactive oxygen species (ROS) production and …
[HTML][HTML] Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5-colorectal cancer cells
Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell
populations, including a pool of cancer stem cells that express LGR5. Whether these distinct …
populations, including a pool of cancer stem cells that express LGR5. Whether these distinct …
Mosaic loss of Chromosome Y in aged human microglia
MC Vermeulen, R Pearse, T Young-Pearse… - Genome …, 2022 - genome.cshlp.org
Mosaic loss of Chromosome Y (LOY) is a common acquired structural mutation in the
leukocytes of aging men that is correlated with several age-related diseases, including …
leukocytes of aging men that is correlated with several age-related diseases, including …
[HTML][HTML] CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells
Background: Cisplatin is one of the frontline anticancer agents. However, development of
cisplatin-resistance limits the therapeutic efficacy of cisplatin-based treatment. The …
cisplatin-resistance limits the therapeutic efficacy of cisplatin-based treatment. The …
[HTML][HTML] Expression of androgen and estrogen receptors in the human lacrimal gland
Lacrimal gland dysfunction causes dry eye disease (DED) due to decreased tear production.
Aqueous-deficient DED is more prevalent in women, suggesting that sexual dimorphism of …
Aqueous-deficient DED is more prevalent in women, suggesting that sexual dimorphism of …