High‐throughput metabolomics by 1D NMR

A Vignoli, V Ghini, G Meoni, C Licari… - Angewandte Chemie …, 2019 - Wiley Online Library
Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

[HTML][HTML] Complex roles of nicotinamide N-methyltransferase in cancer progression

W Wang, C Yang, T Wang, H Deng - Cell Death & Disease, 2022 - nature.com
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing
the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which …

Uniqueness of the NMR approach to metabolomics

PG Takis, V Ghini, L Tenori, P Turano… - TrAC Trends in Analytical …, 2019 - Elsevier
NMR measures a relatively small portion of the human metabolome, which roughly
corresponds to all free small molecules present in concentrations≥ 1 μM. However, the …

Fingerprinting and profiling in metabolomics of biosamples

V Ghini, G Meoni, A Vignoli, F Di Cesare… - Progress in Nuclear …, 2023 - Elsevier
This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

[HTML][HTML] Recent discoveries of diagnostic, prognostic and predictive biomarkers for pancreatic cancer

A Khomiak, M Brunner, M Kordes, S Lindblad… - Cancers, 2020 - mdpi.com
Simple Summary Biomarkers for cancer diagnosis, prognosis and prediction are important
tools and an urgent need in precision medicine for pancreatic cancer. In recent years, many …

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation

D Mastrangelo, E Pelosi, G Castelli, F Lo-Coco… - Blood Cells, Molecules …, 2018 - Elsevier
Abstract Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical
processes. Vit C is an essential nutrient with redox functions at normal physiologic …

Preanalytical processing and biobanking procedures of biological samples for metabolomics research: A white paper, community perspective (for “Precision medicine …

JA Kirwan, L Brennan, D Broadhurst, O Fiehn… - Clinical …, 2018 - academic.oup.com
BACKGROUND The metabolome of any given biological system contains a diverse range of
low molecular weight molecules (metabolites), whose abundances can be affected by the …

[HTML][HTML] Current state of “omics” biomarkers in pancreatic cancer

B Turanli, E Yildirim, G Gulfidan, KY Arga… - Journal of Personalized …, 2021 - mdpi.com
Pancreatic cancer is one of the most fatal malignancies and the seventh leading cause of
cancer-related deaths related to late diagnosis, poor survival rates, and high incidence of …

Pathology assessment of pancreatic cancer following neoadjuvant treatment: time to move on

C Verbeke, L Häberle, D Lenggenhager, I Esposito - Pancreatology, 2018 - Elsevier
Neoadjuvant treatment has increasingly become an integral part of the multimodal
management of patients with pancreatic cancer. In patients who are able to undergo surgery …

[HTML][HTML] Plasma metabolomics predicts chemotherapy response in advanced pancreatic cancer

H Muranaka, A Hendifar, A Osipov, N Moshayedi… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is a clinically heterogeneous disease, and treatment
leads to different outcomes for people with similar diagnoses. Identifying patients who may …