Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
[HTML][HTML] The role of SARS-CoV-2 accessory proteins in immune evasion
Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2
genome encodes some accessory proteins that are essential for infection. Notably …
genome encodes some accessory proteins that are essential for infection. Notably …
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2
S Gahbauer, GJ Correy, M Schuller… - Proceedings of the …, 2023 - National Acad Sciences
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome-coronavirus-2
(SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for …
(SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for …
[HTML][HTML] Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase
Z Wang, L Yang, X Song - Frontiers in Immunology, 2022 - frontiersin.org
GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …
Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study
Background Viral rebound after nirmatrelvir–ritonavir treatment has implications for the
clinical management and isolation of patients with COVID-19. We evaluated an unselected …
clinical management and isolation of patients with COVID-19. We evaluated an unselected …
[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development
S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …
global pandemic, which has seriously affected human health worldwide. The discovery of …
Mechanisms and regulation of defensins in host defense
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
COVID-DSNet: A novel deep convolutional neural network for detection of coronavirus (SARS-CoV-2) cases from CT and Chest X-Ray images
Abstract COVID-19 (SARS-CoV-2), which causes acute respiratory syndrome, is a
contagious and deadly disease that has devastating effects on society and human life …
contagious and deadly disease that has devastating effects on society and human life …
A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …