[HTML][HTML] Evaluation of novel Anti-SARS-CoV-2 compounds by targeting nucleoprotein and envelope protein through homology modeling, docking simulations, ADMET …

EI Edache, A Uzairu, PA Mamza, GA Shallangwa… - Intelligent …, 2024 - Elsevier
The current prominent virus that induces severe acute respiratory syndrome is SARS-CoV-2.
The incidence of COVID-19 cases is increasing, necessitating the immediate development …

Interfering with the reactive cysteine proteome in COVID-19

M Martinez-Banaclocha - Current Medicinal Chemistry, 2022 - ingentaconnect.com
Although vaccination against SARS-CoV-2 infection has been initiated, effective therapies
for severe COVID-19 disease are still needed. A promising therapeutic strategy is using FDA …

Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral …

B Mhlekude, D Postmus, J Weiner 3rd, S Stenzel… - bioRxiv, 2022 - biorxiv.org
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been
suggested as potential therapeutics against SARS-CoV-2 infection. However, molecular …

Analysis of coronavirus envelope protein with cellular automata model

R Hazari, P Pal Chaudhuri - International Journal of Parallel …, 2022 - Taylor & Francis
The reason of significantly higher transmissibility of SARS Covid (2019 CoV-2) compared
with SARS Covid (2003 CoV) and MERS Covid (2012 MERS) can be attributed to mutations …

The Flexible, Extended Alpha Helix Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity

D Schoeman, R Cloete, BC Fielding - 2022 - preprints.org
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …

COVID-19 pathogenesis and host immune response

S Bihani, S Aggarwal… - Multi-Pronged Omics …, 2022 - api.taylorfrancis.com
Pathogenesis by an infecting organism is a victory of pathogen infectivity on the targeted
host. It is often precipitated by the insufficiency of the host immune system to tackle the …

[PDF][PDF] SARS-Cov-2: Interaction Between Mutations and Variants and Their Influence on Treatment and Preventive Strategies

MF Qureshi - J Gstro Hepato, 2022 - researchgate.net
Since the emergence of the SARS-CoV-2 induced COVID-19 pandemic, millions of patients
have been diagnosed for the disease and many of them have died worldwide. SARS-CoV-2 …

[PDF][PDF] The Flexible, Extended Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity. Viruses 2022, 14, 1707

D Schoeman, R Cloete, BC Fielding - 2022 - researchgate.net
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …

[PDF][PDF] NOTABLE VARIANTS OF SARS COV 2 VIRUS-A MINI-REVIEW

E Lawani-Luwaji, T Alade, BU John - 2023 - abjournals.org
Viruses undergo mutations over time, and sometimes these changes do not have any significant
impact on the virus's pro Page 1 African Journal of Biology and Medical Research ISSN …

Analysis of Viroporins and Membrane Systems With Native Mass Spectrometry

J Townsend - 2023 - search.proquest.com
Viroporins are a class of viral membrane proteins that play diverse roles in the viral infection
cycle. Viroporins are known to play roles in ion transport, inducing membrane curvature, as …