Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Background: Childhood trauma (CT) has adverse consequences on mental health across
the lifespan. The understanding of how CT increases vulnerability for psychiatric disorders is …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

Background Studies often evaluate mental health and well-being in association with
individual health behaviours although evaluating multiple health behaviours that co-occur in …

Mitochondria are subcellular organelles known for their central role in several energetic
processes. Accumulating evidence supports a key role for mitochondria in the physiological …

Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …

In seeking to understand mental health and disease, it is fundamental to identify the
biological substrates that draw together the experiences and physiological processes that …

We have developed a deep learning aging clock using blood test data from the China
Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years …