[HTML][HTML] Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
[HTML][HTML] The signaling pathways and therapeutic potential of itaconate to alleviate inflammation and oxidative stress in inflammatory diseases
X Shi, H Zhou, J Wei, W Mo, Q Li, X Lv - Redox biology, 2022 - Elsevier
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
[HTML][HTML] Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors
X Wang, S Su, Y Zhu, X Cheng, C Cheng… - Nature …, 2023 - nature.com
The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is
essentially affecting their capacity of combating tumor cells. Here we find, via a pooled …
essentially affecting their capacity of combating tumor cells. Here we find, via a pooled …
Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
[HTML][HTML] Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
K Aso, M Kono, M Kanda, Y Kudo, K Sakiyama… - Nature …, 2023 - nature.com
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many
autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite …
autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite …
[HTML][HTML] Itaconate is a lysosomal inducer that promotes antibacterial innate immunity
Lysosomes are the main organelles in macrophages for killing invading bacteria. However,
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …
the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …
[HTML][HTML] Obesity-induced inflammation exacerbates clonal hematopoiesis
SK Pasupuleti, B Ramdas, SS Burns… - The Journal of …, 2023 - Am Soc Clin Investig
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis
Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported
into the cytosol to exert multiple regulatory effects in macrophages. However, the …
into the cytosol to exert multiple regulatory effects in macrophages. However, the …
[HTML][HTML] TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
[HTML][HTML] 4-Octyl itaconate restricts STING activation by blocking its palmitoylation
The cyclic guanosine monophosphate adenosine monophosphate synthase (cGAS)-
stimulator of interferon genes (STING) axis plays a vital role in defending foreign pathogens …
stimulator of interferon genes (STING) axis plays a vital role in defending foreign pathogens …