X Shi, H Zhou, J Wei, W Mo, Q Li, X Lv - Redox biology, 2022 - Elsevier
Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …
X Wang, S Su, Y Zhu, X Cheng, C Cheng… - Nature …, 2023 - nature.com
The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is essentially affecting their capacity of combating tumor cells. Here we find, via a pooled …
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
K Aso, M Kono, M Kanda, Y Kudo, K Sakiyama… - Nature …, 2023 - nature.com
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite …
Z Zhang, C Chen, F Yang, YX Zeng, P Sun, P Liu, X Li - Molecular Cell, 2022 - cell.com
Lysosomes are the main organelles in macrophages for killing invading bacteria. However, the precise mechanism underlying lysosomal biogenesis upon bacterial infection remains …
SK Pasupuleti, B Ramdas, SS Burns… - The Journal of …, 2023 - Am Soc Clin Investig
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the …
C Chen, Z Zhang, C Liu, P Sun, P Liu, X Li - Cell Metabolism, 2024 - cell.com
Itaconate is a metabolite that synthesized from cis-aconitate in mitochondria and transported into the cytosol to exert multiple regulatory effects in macrophages. However, the …
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
C Su, T Cheng, J Huang, T Zhang, H Yin - Cell reports, 2023 - cell.com
The cyclic guanosine monophosphate adenosine monophosphate synthase (cGAS)- stimulator of interferon genes (STING) axis plays a vital role in defending foreign pathogens …