Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

Z Xu, X Han, D Ou, T Liu, Z Li, G Jiang, J Liu… - Applied microbiology …, 2020 - Springer
Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets

F Shu, H Xiao, QN Li, XS Ren, ZG Liu, BW Hu… - … and Targeted Therapy, 2023 - nature.com
Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Crosstalk between autophagy and microbiota in cancer progression

Y Wang, J Du, X Wu, A Abdelrehem, Y Ren, C Liu… - Molecular Cancer, 2021 - Springer
Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a
lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often …

TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses

M Di Rienzo, A Romagnoli, M Antonioli… - Cell Death & …, 2020 - nature.com
Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway

X Wu, Y Jiang, R Li, Y Xia, F Li, M Zhao, G Li… - Cell Death & …, 2023 - nature.com
Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has
harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that …

The roles of ubiquitin in mediating autophagy

Z Yin, H Popelka, Y Lei, Y Yang, DJ Klionsky - Cells, 2020 - mdpi.com
Ubiquitination, the post-translational modification essential for various intracellular
processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole …

Therapeutic potential of PI3K/AKT/mTOR pathway in gastrointestinal stromal tumors: rationale and progress

Y Duan, J Haybaeck, Z Yang - Cancers, 2020 - mdpi.com
Simple Summary Most gastrointestinal stromal tumors (GISTs) arise due to gain-of-function
mutations of KIT and PDGFRA, encoding the receptor tyrosine kinase (RTK). The …

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages

A Romagnoli, M Di Rienzo, E Petruccioli, C Fusco… - Cell Death & …, 2023 - nature.com
Mycobacterium tuberculosis (Mtb) is known to evade host immune responses and persist in
macrophages for long periods. A mechanism that the host uses to combat Mtb is xenophagy …

TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination

J Zhang, H Xie, J Yao, W Jin, H Pan, Z Pan, D Xie… - Human Cell, 2023 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease around the
world. However, no specific medicine has been approved for NAFLD treatment. Our study …

Identification of a five-autophagy-related-lncRNA signature as a novel prognostic biomarker for hepatocellular carcinoma

X Deng, Q Bi, S Chen, X Chen, S Li, Z Zhong… - Frontiers in Molecular …, 2021 - frontiersin.org
Although great progresses have been made in the diagnosis and treatment of hepatocellular
carcinoma (HCC), its prognostic marker remains controversial. In this current study …