Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

目的循证评价多国超说明书用药相关法律, 法规, 指南等, 为规范我国超说明书用药提供参考.
方法计算机检索CBM, CNKI, VIP3 个中文数据库, EMbase, PubMed 等11 个外文数据库以及15 …

Abstract Background and Aims Since its market release, gabapentin has been presumed to
have no abuse potential and subsequently has been prescribed widely off‐label, despite …

Highlights•Drug repositioning and similar terms have been a trending topic since
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …

The 21st Century Cures Act passed by the United States Congress mandates the US Food
and Drug Administration to develop guidance to evaluate the use of real‐world evidence …

Importance Off-label use of prescription drugs has been identified as an important
contributor to preventable adverse drug events (ADEs) in children. Despite concerns …

DrugCentral monitors new drug approvals and standardizes drug information. The current
update contains 285 drugs (131 for human use). New additions include:(i) the integration of …

The term off-label drug use (OLDU) is used extensively in the medical literature, continuing
medical education exercises, and the media. Yet, we propose that many health care …

Objective To examine off-label indications for antidepressants in primary care and determine
the level of scientific support for off-label prescribing. Design Descriptive study of …