Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …

Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Liquid-liquid phase separation (LLPS) has received significant attention in recent biological
studies. It refers to a phenomenon that biomolecule exceeds the solubility, condensates and …

Protein post-translational modification (PTM) is an important regulatory mechanism that
plays a key role in both normal and disease states. Acetylation on lysine residues is one of …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene
transcription via lactylation of histones and non-histone proteins, ie, a novel posttranslational …

Colorectal cancer (CRC) is one of the costliest health problems and ranks second in cancer-
related mortality in developed countries. With the aid of proteomics, many protein …

DNA repair is a tightly coordinated stress response to DNA damage, which is critical for
preserving genome integrity. Accruing evidence suggests that metabolic pathways have …

Ubiquitylation is catalyzed by coordinated actions of E3 and E2 enzymes. Molecular
principles governing many important E3-E2 partnerships remain unknown, including those …

Metabolic reactions within cells occur in various isolated compartments with or without
borders, the latter being known as membrane-less organelles (MLOs). The MLOs show …