Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …

Groundbreaking structural and spectroscopic studies of class AG protein-coupled receptors
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …

The γ-aminobutyric acid (GABA) type B receptor (GABAB-R) belongs to class C of the G-
protein coupled receptors (GPCRs). Together with the GABAA receptor, the receptor …

Background Identifying biomarkers associated with Alzheimer's disease (AD) progression
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …

Schizophrenia is considered primarily as a cognitive disorder. However, functional
outcomes in schizophrenia are limited by the lack of effective pharmacological and …

An imbalance of excitatory and inhibitory neurotransmission leading to over excitation plays
a crucial role in generating seizures, while enhancing GABAergic mechanisms are critical in …