Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance-A review

TM Al-Noshokaty, A Mansour, R Abdelhamid… - … -Research and Practice, 2023 - Elsevier
Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The
lack of reliable means of early cancer detection contributes to this disease's dismal …

[HTML][HTML] Macrophages in pancreatitis: Mechanisms and therapeutic potential

F Hu, N Lou, J Jiao, F Guo, H Xiang, D Shang - Biomedicine & …, 2020 - Elsevier
Macrophages play a crucial role in the pathogenesis of pancreatitis that is a common
gastrointestinal disease. Particularly, macrophages differentiate into different phenotypes …

Hypoxia induces immunosuppression, metastasis and drug resistance in pancreatic cancers

H Zhang, K Cao, J Xiang, M Zhang, M Zhu, Q Xi - Cancer Letters, 2023 - Elsevier
Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

[HTML][HTML] Mechanisms of obesity-and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review

R Ruze, J Song, X Yin, Y Chen, R Xu… - Signal transduction and …, 2023 - nature.com
Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

[HTML][HTML] The potential roles of exosomes in pancreatic cancer initiation and metastasis

W Sun, Y Ren, Z Lu, X Zhao - Molecular cancer, 2020 - Springer
Pancreatic cancer (PaCa) is an insidious and highly metastatic malignancy, with a 5-year
survival rate of less than 5%. So far, the pathogenesis and progression mechanisms of …

Targeting hedgehog signaling in pancreatic ductal adenocarcinoma

D Quatannens, Y Verhoeven, P Van Dam… - Pharmacology & …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer related
death. The urgent need for effective therapies is highlighted by the lack of adequate …

[HTML][HTML] New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets

YC Lin, YC Hou, HC Wang, YS Shan - Theranostics, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …

[HTML][HTML] Exosomes: the key of sophisticated cell–cell communication and targeted metastasis in pancreatic cancer

H Zhang, J Xing, Z Dai, D Wang, D Tang - Cell Communication and …, 2022 - Springer
Pancreatic cancer is one of the most common malignancies. Unfortunately, the lack of
effective methods of treatment and diagnosis has led to poor prognosis coupled with a very …

[HTML][HTML] EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway

J Xu, W Zhang - Cancer cell international, 2021 - Springer
Background As a member of the ERM (ezrin-radixin-moesin) protein family, EZR has been
recognized as a regulator of adhesion signal pathways by researchers. Moreover, EZR was …

[HTML][HTML] Long non-coding RNAs and pancreatic cancer: A multifaceted view

B Wang, C Yuan, Y Qie, S Dang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Pancreatic cancer (PC) is a highly malignant disease with a 5-year survival rate of only 10%.
Families with PC are at greater risk, as are type 2 diabetes, pancreatitis, and other factors …