[HTML][HTML] Stimuli-activatable nanomedicine meets cancer theranostics

H Li, Y Feng, Q Luo, Z Li, X Li, H Gan, Z Gu, Q Gong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.
Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable nanomedicine …

Preparation and application of pH-responsive drug delivery systems

H Ding, P Tan, S Fu, X Tian, H Zhang, X Ma… - Journal of Controlled …, 2022 - Elsevier
Microenvironment-responsive drug delivery systems (DDSs) can achieve targeted drug
delivery, reduce drug side effects and improve drug efficacies. Among them, pH-responsive …

pH‐responsive polymer nanoparticles for drug delivery

N Deirram, C Zhang, SS Kermaniyan… - Macromolecular …, 2019 - Wiley Online Library
Stimuli‐responsive nanoparticles have the potential to improve the delivery of therapeutics
to a specific cell or region within the body. There are many stimuli that have shown potential …

pH-sensitive biomaterials for drug delivery

S Zhuo, F Zhang, J Yu, X Zhang, G Yang, X Liu - Molecules, 2020 - mdpi.com
The development of precise and personalized medicine requires novel formulation
strategies to deliver the therapeutic payloads to the pathological tissues, producing …

[HTML][HTML] Dilemma and breakthrough of biodegradable poly-l-lactic acid in bone tissue repair

J Zan, G Qian, F Deng, J Zhang, Z Zeng, S Peng… - Journal of Materials …, 2022 - Elsevier
The repair of segmental bone defects caused by traumatic injury or pathological diseases
remains a substantial challenge in clinic. Poly-l-lactic acid (PLLA) is recognized as one …

[HTML][HTML] Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

X Shen, D Pan, Q Gong, Z Gu, K Luo - Bioactive Materials, 2024 - Elsevier
Effective tumor treatment depends on optimizing drug penetration and accumulation in
tumor tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key …

Self-driven electrical stimulation-promoted cancer catalytic therapy and chemotherapy based on an implantable nanofibrous patch

M Zheng, S Yao, Y Zhao, X Wan, Q Hu… - … Applied Materials & …, 2023 - ACS Publications
The efficacy of cancer catalytic therapy is still hindered by the inefficient generation of
reactive oxygen species (ROS). Herein, we report a self-driven electrical stimulation …

Metal organic frameworks as a compatible reinforcement in a biopolymer bone scaffold

Y Yang, J Zan, W Yang, F Qi, C He, S Huang… - Materials Chemistry …, 2020 - pubs.rsc.org
The insufficient mechanical strength and slow degradation rate of poly-L-lactic acid (PLLA)
limit its applications in bone repair. In this study, zeolitic imidazolate framework-8 (ZIF-8) …

Highly stable, coordinated polymeric nanoparticles loading copper (II) diethyldithiocarbamate for combinational chemo/chemodynamic therapy of cancer

X Peng, Q Pan, B Zhang, S Wan, S Li, K Luo… - …, 2019 - ACS Publications
Disulfiram (DSF) has excellent in vitro anticancer activity in the presence of Cu (II). The
anticancer mechanism studies have demonstrated that copper (II) diethyldithiocarbamate …

Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

B Zhang, S Wan, X Peng, M Zhao, S Li, Y Pu… - Journal of materials …, 2020 - pubs.rsc.org
Doxorubicin (DOX) is a widely-used anticancer drug, but its cardiotoxicity severely hampers
its potency in chemotherapy. Herein, human serum albumin (HSA) is engaged as a …