Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian
reproductive function in both males and females. It acts via G-protein coupled receptors on …

Background: Since the discovery of cardiac hormones almost 25 years ago, a vast amount of
clinical research has identified the cardiac natriuretic peptides and their precursors as …

Angiotensin receptor blockade and neprilysin (NEP) inhibition together offer potential
benefits for the treatment of hypertension and heart failure. LCZ696 is a novel single …

C-terminal brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for
the diagnosis, prognosis, and treatment of heart failure (HF). The 32-aa peptide is …

The present study investigates why shedding of the endothelial glycocalyx occurs both in
patients undergoing on-and off-pump coronary artery bypass surgery. Release of atrial …

Abstract This 8-week, multi-center, open-label study assessed the safety and efficacy of
LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Japanese patients with …

Acute lung injury, sepsis, lung inflammation, and ventilator‐induced lung injury are life‐
threatening conditions associated with lung vascular barrier dysfunction, which may lead to …

Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3
mechanisms: increased renal excretion of salt and water, vasodilation, and increased …

We investigated whether atrial natriuretic peptide (ANP) given just prior to reperfusion
reduces infarction in rabbit hearts and whether protection is related to activation of protein …

Abstract Background Kraits (genus Bungarus) and cobras (genus Naja) are two
representative toxic genera of elapids in the old world. Although they are closely related …