Microtubule (MT) dynamics is involved in a variety of cell functions, including control of the
endothelial cell (EC) barrier. Release of Rho-specific nucleotide exchange factor GEF-H1 …

Abstract Glucagon-like peptide-1 (GLP-1) is protective in lung disease models but the
underlying mechanisms remain elusive. Because the hormone atrial natriuretic peptide …

Various heart diseases present with sudden death; however, it is difficult to interpret the
severity of or difference in respective preexisting and terminal cardiac dysfunction based on …

The circulating concentration of a biomarker for congestive heart failure, Brain (B-type)
Natriuretic Peptide (BNP-32), is measured using ELISA based assays in order to rapidly …

Heart failure is a global problem with elevated prevalence, and it is associated with
substantial cardiovascular morbidity and mortality. Treating heart-failure patients has been a …

Background: Total homocysteine (tHcy) has been linked to the severity of chronic heart
failure (CHF). Elevated tHcy concentrations are mainly caused by folate and vitamin B-12 …

Although the mechanism underlying C-type natriuretic peptide (CNP) beneficial effects is not
entirely understood, modulating the expression of matrix metalloproteinases (MMPs)/tissue …

Atrial natriuretic peptide (ANP) has known natriuretic, diuretic, and vasodilatatory effects. It is
synthesized and stored in the atrial cells. Stretching of the atrial muscle fibers during an …

The present application is a continuation of US patent application Ser. No. 10/107.814, filed
Mar. 28, 2002 now US Pat. No. 7,041,786 and claims the benefit of US Patent Application …

Heart failure is a progressive and often fatal disease process. In general, the
pathophysiologic mechanisms responsible for progressive myocyte dysfunction and cell …