There is a sex difference in the hypothalamo-pituitary-adrenal (HPA) axis of many species,
although there are sparse data on the sheep. In the present study we have compared the …

As the ultimate pathophysiological event, heart failure (HF) may arise from various
cardiovascular (CV) conditions, including sustained pressure/volume overload of the left …

OBJECTIVES: To determine whether acute left ventricular dysfunction (LVD) causes
significantly higher elevation of N-terminal pro-B–type natriuretic peptide (NT-proBNP) …

C-type natriuretic peptide (CNP) is a peptide produced by the vascular endothelium with
vasodilative properties. It shares structural and physiological properties with the atrial and …

Abstract Background and Purpose Angiotensin receptor-NEP inhibitor (ARNi), which
includes an angiotensin receptor blocker (ARB) and a neprilysin inhibitor (NEPi), has been …

Die chronische Herzinsuffizienz ist eine fortschreitende Erkrankung, die bei vielen Patienten
zum Tode führt. Veränderungen in der intrazellulären Signaltransduktion sowie in der …

Progressive ventricular hypertrophy can lead to the development of insulin resistance, a
feature of both chronic kidney disease and heart failure. Here we induced uremia in adult …

Abstract LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), is
comprised of the angiotensin receptor blocker valsartan and the neprilysin inhibitor pro-drug …

The cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary
arterial blood pressure by activation of its cyclic GMP-producing guanylyl cyclase-A (GC-A) …

OBJECTIVE: In this study, our purpose was to determine whether plasma BNP level can be
useful or not in determining the severity of myocardial injury formed by CO poisoning and to …