An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

TRPC3 and TRPC6 channels are calcium-permeable non-selective cation channels that are
involved in many physiological processes. The gain-of-function (GOF) mutations of TRPC6 …

Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease.
Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Sustained imbalance in intracellular calcium (Ca2+) entry and clearance alters cellular
integrity, ultimately leading to cellular homeostasis disequilibrium and cell death …

Intracellular Ca2+ dysregulation is a key marker in septic cardiac dysfunction; however,
regulation of the classic Ca2+ regulatory modules cannot successfully abolish this symptom …

Pulsing electromagnetic fields (PEMFs) have been shown to promote in vitro and in vivo
myogeneses via mitohormetic survival adaptations of which secretome activation is a key …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …