Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli
with abnormal sensations, such as dryness, blurring, foreign body sensation, discomfort …

Cardiovascular disease is the leading cause of death, medical complications, and
healthcare costs. Although recent advances have been in treating cardiovascular disorders …

Ischemic stroke is one of the most disabling diseases and a leading cause of death globally.
Despite advances in medical care, the global burden of stroke continues to grow, as no …

For decades, chronic diseases including cardiovascular and cerebrovascular diseases
(CCVDs) have plagued the world. Meanwhile, we have noticed a close association between …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Transient receptor potential canonical (TRPC) channels belong to an important class of non-
selective cation channels. This channel family consists of multiple members that widely …

Transient receptor potential canonical (TRPC) channels are the most prominent
nonselective cation channels involved in various diseases. However, the function, clinical …

Canonical transient receptor potential 3 (TRPC3) channel is a non-selective cation
permeable channel that plays an essential role in calcium signalling. TRPC3 is highly …

Heart failure is a serious global health challenge, affecting more than 6.2 million people in
the United States and is projected to reach over 8 million by 2030. Independent of etiology …

Abstract The mammalian Transient Receptor Potential Canonical (TRPC) subfamily
comprises seven transmembrane proteins (TRPC1–7) forming cation channels in the …