The acute release of neutrophils from the bone marrow is a critical step in their trafficking to
sites of inflammation. This process is stimulated by systemically acting inflammatory …

Requirements for leukocyte adhesion molecules as well as cytokines have been determined
in the rat model of acute nephrotoxic nephritis. Proteinuria (at 24 h) and neutrophil …

The production of several cytokines such as interleukin (IL)-1 in gastric mucosa is increased
in subjects infected with Helicobacter pylori, a bacterium associated with ulcer recurrence …

The aim of this investigation was to identify the mechanism by which nitric oxide inhibits
neutrophil β2 integrin dependent adherence. Isolated rat neutrophils from blood and …

Connective tissue growth factor (CTGF) is a mitogenic, chemotactic, and cell matrix-inducing
factor for fibroblasts. We generated murine monoclonal antibodies against CTGF and …

In patients with glomerulonephritis widespread crescents are associated with a poor
prognosis. Crescent formation appears to depend on the migration of mononuclear cells into …

When leukocytes adhere to endothelial cells and are exposed to fluid shear stresses, they
often retract pseudopods and reduce their attachment. Leukocytes use CD18 for membrane …

A role for the alpha 4-integrin (alpha 4 beta 1 or alpha 4 beta 7), has been implicated in the
recruitment of peripheral blood mononuclear cells (PBMCs) to sites of inflammation …

The β 2 integrin cell adhesion molecules (CAM) mediate polymorphonuclear leukocyte
(PMNL) emigration in most inflamed tissues, but, in the lung, other yet to be identified CAMs …

Blood neutrophils contribute to joint injury in human and experimental models of arthritis.
Neutrophil migration out of the blood in joint inflammation involves both the CD18 (beta2) …