Neurosecretory protein VGF (non-acronymic) belongs to the granin family of neuropeptides.
VGF and VGF-derived peptides have been repeatedly identified in well-powered and well …

The diagnosis of neurodegenerative disorders is often challenging due to the lack of
diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction …

Though discovered over 100 years ago, the molecular foundation of sporadic Alzheimer's
disease (AD) remains elusive. To better characterize the complex nature of AD, we …

Introduction: Biomarkers that reflect pathologic processes affecting neuronal function during
preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug …

Asymptomatic and symptomatic Alzheimer's disease (AD) subjects may present with
equivalent neuropathological burdens but have significantly different antemortem cognitive …

Scope The aim of this study was to develop and evaluate a parallel reaction monitoring
mass spectrometry (PRM‐MS) assay consisting of a panel of potential protein biomarkers in …

With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …

Background Multiomic studies by several groups in the NIH Accelerating Medicines
Partnership for Alzheimer's Disease (AMP-AD) identified VGF as a major driver of …

Alzheimer's disease (AD) is the most common form of dementia affecting 60%–70% of
people afflicted with this disease. Accurate antemortem diagnosis is urgently needed for …

Background During the last two decades, over 100 proteomics studies have identified a
variety of potential biomarkers in CSF of Alzheimer's (AD) patients. Although several reviews …