Cancer and aging are accompanied by stereotyped changes to the epigenetic landscape,
including progressive loss of DNA methylation over gene-poor genomic regions (,). Global …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Single-cell chromatin accessibility sequencing (scATAC-seq) reconstructs developmental
trajectory by phenotypic similarity. However, inferring the exact developmental trajectory is …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Several interventions have recently emerged that were proposed to reverse rather than just
attenuate aging, but the criteria for what it takes to achieve rejuvenation remain …

Recent research revealed a rejuvenation event during early development of mice. Here, by
examining epigenetic age dynamics of human embryogenesis, we tested whether a similar …

Recent advances in sequencing technologies provide unprecedented opportunities for
epigenetic biomarker development. Particularly the DNA methylation pattern—which is …

Abstract N6‐methyladenosine (m6A) is a dynamic and reversible RNA modification that has
emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various …