Chronological age reveals the number of years an individual has lived since birth. By
contrast, biological age varies between individuals of the same chronological age at a rate …

Recent studies suggest the existence of a natural rejuvenation event during early embryonic
development of mice, followed by epigenetic aging. Here, by profiling embryonic DNA …

Epigenetic aging clocks have been widely used to validate rejuvenation effects during
cellular reprogramming. However, these predictions are unverifiable because the true …

Aging and regeneration represent complex biological phenomena that have long captivated
the scientific community. To fully comprehend these processes, it is essential to investigate …

Background: Genetic and epigenetic changes, oxidative stress and inflammation influence
the rate of aging, which diseases, lifestyle and environmental factors can further accelerate …

Aging is a complex and time-dependent decline in physiological function that affects most
organisms, leading to increased risk of age-related diseases. Investigating the molecular …

Over the past decade, advances in single-cell omics (SCO) technologies have enabled the
investigation of cellular heterogeneity at an unprecedented resolution and scale, opening a …

Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

Aging is the single largest risk factor for most chronic diseases, and thus possesses large
socioeconomic interest to continuously aging societies. Consequently, the field of aging …

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing
brain function during aging. The microbial diversity of the human gut microbiome decreases …