After the pandemic: perspectives on the future trajectory of COVID-19

A Telenti, A Arvin, L Corey, D Corti, MS Diamond… - Nature, 2021 - nature.com
There is a realistic expectation that the global effort in vaccination will bring the pandemic
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) under control …

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

W Hoepel, HJ Chen, CE Geyer… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Antibody development after COVID-19 vaccination in patients with autoimmune diseases in the Netherlands: a substudy of data from two prospective cohort studies

L Boekel, M Steenhuis, F Hooijberg… - The Lancet …, 2021 - thelancet.com
Background Data are scarce on immunogenicity of COVID-19 vaccines in patients with
autoimmune diseases, who are often treated with immunosuppressive drugs. We aimed to …

Humoral responses after second and third SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders on immunosuppressants: a cohort study

L Wieske, KPJ van Dam, M Steenhuis… - The Lancet …, 2022 - thelancet.com
Background Disease-specific studies have reported impaired humoral responses after
SARS-CoV-2 vaccination in patients with immune-mediated inflammatory disorders treated …

Breakthrough SARS-CoV-2 infections with the delta (B. 1.617. 2) variant in vaccinated patients with immune-mediated inflammatory diseases using …

L Boekel, EW Stalman, L Wieske… - The Lancet …, 2022 - thelancet.com
Background Concerns have been raised regarding the risks of SARS-CoV-2 breakthrough
infections in vaccinated patients with immune-mediated inflammatory diseases treated with …

Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial

H Bian, ZH Zheng, D Wei, A Wen, Z Zhang… - Signal transduction and …, 2021 - nature.com
Abstracts Recent evidence suggests that CD147 serves as a novel receptor for severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Blocking CD147 via anti …

[HTML][HTML] Hyperimmune immunoglobulin for people with COVID‐19

C Kimber, SJ Valk, KL Chai, V Piechotta… - … of systematic reviews, 2023 - ncbi.nlm.nih.gov
Background Hyperimmune immunoglobulin (hIVIG) contains polyclonal antibodies, which
can be prepared from large amounts of pooled convalescent plasma or prepared from …

Immune dynamics in SARS-CoV-2 experienced immunosuppressed rheumatoid arthritis or multiple sclerosis patients vaccinated with mRNA-1273

NJM Verstegen, RR Hagen, J van den Dijssel… - Elife, 2022 - elifesciences.org
Background: Patients affected by different types of autoimmune diseases, including common
conditions such as multiple sclerosis (MS) and rheumatoid arthritis (RA), are often treated …

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

J Van Coillie, T Pongracz, J Rahmöller, HJ Chen… - …, 2023 - thelancet.com
Summary Background Afucosylated IgG1 responses have only been found against
membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These …

Impact of immunosuppressive treatment and type of SARS-CoV-2 vaccine on antibody levels after three vaccinations in patients with chronic kidney disease or kidney …

P Bouwmans, AL Messchendorp, C Imhof… - Clinical kidney …, 2023 - academic.oup.com
Background Patients with chronic kidney disease (CKD) or kidney replacement therapy
demonstrate lower antibody levels after severe acute respiratory syndrome coronavirus 2 …