A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

DR Martinez, A Schäfer, S Gobeil, D Li… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronaviruses 1 (SARS-CoV) and 2 (SARS-CoV-2),
including SARS-CoV-2 variants of concern, can cause deadly infections. The mortality …

[HTML][HTML] Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

B Ju, Q Zhang, Z Wang, ZQ Aw, P Chen, B Zhou… - Nature …, 2023 - nature.com
The omicron variants of SARS-CoV-2 have substantial ability to escape infection-and
vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine …

[PDF][PDF] Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

[HTML][HTML] Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …

[HTML][HTML] Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Z Fang, L Peng, R Filler, K Suzuki, A McNamara… - Nature …, 2022 - nature.com
The Omicron variant of SARS-CoV-2 recently swept the globe and showed high level of
immune evasion. Here, we generate an Omicron-specific lipid nanoparticle (LNP) mRNA …

[HTML][HTML] SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization

D Mannar, JW Saville, Z Sun, X Zhu, MM Marti… - Nature …, 2022 - nature.com
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently
been shown to enhance aspects of spike protein fitness. Here, we describe an antibody …

[HTML][HTML] Booster of mRNA-1273 strengthens SARS-CoV-2 Omicron neutralization

NA Doria-Rose, X Shen, SD Schmidt, S O'Dell… - MedRxiv, 2021 - ncbi.nlm.nih.gov
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased
transmissibility and potential for reduced susceptibility to antibody neutralization. To assess …

An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

N Ikemura, S Taminishi, T Inaba, T Arimori… - Science translational …, 2022 - science.org
The Omicron (B. 1.1. 529) SARS-CoV-2 variant contains an unusually high number of
mutations in the spike protein, raising concerns of escape from vaccines, convalescent …

[PDF][PDF] Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

M Gagne, KS Corbett, BJ Flynn, KE Foulds, DA Wagner… - Cell, 2022 - cell.com
Summary mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time;
however, there are limited data on the impact of durability of immune responses on …

Therapeutic monoclonal antibodies for COVID-19 management: an update

VP Chavda, R Prajapati, D Lathigara… - Expert opinion on …, 2022 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
affected more than 529 million people, and today the world is facing different mutant strains …