There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Gene expression in mammalian cells depends on the epigenetic status of the chromatin,
including DNA methylation, histone modifications, promoter–enhancer interactions, and …

We quantified genome-wide patterns of lysine H3K27 acetylation (H3K27ac) in entorhinal
cortex samples from Alzheimer's disease (AD) cases and matched controls using chromatin …

Alzheimer's disease (AD) is the leading cause of age-related dementia. Neuropathological
hallmarks of AD include brain deposition of β-amyloid (Aβ) plaques and accumulation of …

Neurodegenerative disorders are characterized by the progressive loss of central and/or
peripheral nervous system neurons. Within this context, neuroinflammation comes up as one …

Alzheimer's disease (AD) is a chronic neurodegenerative disease, which is associated with
learning and memory impairment in the elderly. Recent studies have found that treating AD …

Tau is a scaffolding protein that serves multiple cellular functions that are perturbed in
neurodegenerative diseases, including Alzheimer's disease (AD) and frontotemporal …

Epigenetics is a rapidly growing field of biology that studies the changes in gene expression
that are not due to alterations in the DNA sequence but rather the chemical modifications of …

Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …

Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …