The renin angiotensin system as a therapeutic target in traumatic brain injury

S Villapol, ZC Janatpour, KO Affram, AJ Symes - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Is it time for a paradigm shift in the treatment of schizophrenia? the use of inflammation-reducing and neuroprotective Drugs—A review

A Messina, C Concerto, A Rodolico, A Petralia… - Brain Sciences, 2023 - mdpi.com
Comprehending the pathogenesis of schizophrenia represents a challenge for global
mental health. To date, although it is evident that alterations in dopaminergic, serotonergic …

[HTML][HTML] Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension

H Yousef, AH Khandoker, SF Feng, C Helf… - Frontiers in …, 2023 - frontiersin.org
Introduction Type II diabetes mellitus (T2DM) is a metabolic disorder that poses a serious
health concern worldwide due to its rising prevalence. Hypertension (HT) is a frequent …

Angiotensin‐converting enzymes as druggable features of psychiatric and neurodegenerative disorders

TC Santiago, L Parra, JV Nani… - Journal of …, 2023 - Wiley Online Library
The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

Incidence of post-stroke cognitive impairment in patients with first-ever ischemic stroke: a multicenter cross-sectional study in China

A He, Z Wang, X Wu, W Sun, K Yang… - The Lancet Regional …, 2023 - thelancet.com
Background Post-stroke cognitive impairment (PSCI) is a common sequela after stroke.
China has a large population of stroke survivors, but a large-scale survey on the incidence …

Sacubitril/valsartan alleviates sepsis‐induced acute lung injury via inhibiting GSDMD‐dependent macrophage pyroptosis in mice

J Wang, J Li, A Lou, Y Lin, Q Xu, W Cui… - The FEBS …, 2023 - Wiley Online Library
Sepsis‐induced acute lung injury (ALI) is a life‐threatening disorder with intricate
pathogenesis. Macrophage pyroptosis reportedly plays a vital role in ALI. Although it has …

Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement

DE Forman, GA Kuchel, JC Newman… - Journal of the American …, 2023 - jacc.org
Geroscience posits that cardiovascular disease (CVD) and other chronic diseases result
from progressive erosion of the effectiveness of homeostatic mechanisms that oppose age …

Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19

L Kundura, S Gimenez, R Cezar, S André… - Journal of Allergy and …, 2022 - Elsevier
Background Lymphopenia is predictive of survival in patients with coronavirus disease 2019
(COVID-19). Objective The aim of this study was to understand the cause of the lymphocyte …

Potential molecular pathways of angiotensin receptor blockers in the brain toward cognitive improvement in dementia

V Karmakar, B Gorain - Drug Discovery Today, 2023 - Elsevier
The alarming rise of cognitive impairment and memory decline and limited effective
solutions present a worldwide concern for dementia patients. The multivariant role of the …

Innate immune response in hypertension

JB De Sanctis - Current Pharmaceutical Design, 2022 - ingentaconnect.com
Even though an association between inflammation and hypertension has been known for
many years, it has not been simple to ascertain the role of several physiological responses …