During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its
associated diseases. However, the mechanism for this decline is unclear. Here, we show …

Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

Background Traditional metrics for population health ageing tend not to differentiate
between extending life expectancy and adding healthy years. A population ageing metric …

It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

To characterize the proteomic signature of chronological age, 1,301 proteins were
measured in plasma using the SOMAscan assay (SomaLogic, Boulder, CO, USA) in a …

Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases
including osteoarthritis (OA), in part via expression of a senescence-associated secretory …