Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

The study of diseases of the central nervous system (CNS) at the molecular level is
challenging because of the complexity of neural circuits and the huge number of specialized …

There is growing evidence for the role of DNA methylation (DNAm) quantitative trait loci
(mQTLs) in the genetics of complex traits, including psychiatric disorders. However, due to …

Ancestral differences in genomic variation affect the regulation of gene expression; however,
most gene expression studies have been limited to European ancestry samples or adjusted …

DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms …

Introduction DNA methylation (DNAm), an epigenetic mechanism, has been associated with
opioid use disorder (OUD) in preclinical and human studies. However, most of the studies …

Schizophrenia (SCZ) is a severe psychiatric and neurodevelopmental disorder. The
pathological process of SCZ starts early during development, way before the first onset of …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

Background Glioblastoma multiforme and other solid malignancies are heterogeneous,
containing subpopulations of tumor cells that exhibit stem characteristics. Oct4, also known …