A highly immunogenic, protective, and safe adenovirus-based vaccine expressing Middle East respiratory syndrome coronavirus S1-CD40L fusion protein in a …

AM Hashem, A Algaissi, AS Agrawal… - The Journal of …, 2019 - academic.oup.com
Background Infection control measures have played a major role in limiting human/camel-to-
human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV); …

Middle east respiratory syndrome coronavirus (mers-cov): State of the science

A Mostafa, A Kandeil, M Shehata, R El Shesheny… - Microorganisms, 2020 - mdpi.com
Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging
from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members …

Regulatory considerations on the development of mRNA vaccines

R Naik, K Peden - mRNA Vaccines, 2020 - Springer
Developing traditional viral vaccines for infectious diseases usually takes years, as these
are usually produced either by chemical inactivation of the virus or attenuation of the …

Determine the potential epitope based peptide vaccine against novel SARS-CoV-2 targeting structural proteins using immunoinformatics approaches

M Waqas, A Haider, M Sufyan, S Siraj… - Frontiers in molecular …, 2020 - frontiersin.org
Coronaviruses (CoVs) belong to the Coronaviridae-family. The genus Beta-coronaviruses,
are enveloped positive strand RNA viruses with club-like spikes at the surface with a unique …

Amotosalen and ultraviolet A light efficiently inactivate MERS‐coronavirus in human platelet concentrates

AM Hashem, AM Hassan, AM Tolah… - Transfusion …, 2019 - Wiley Online Library
Objective This study aimed to assess the efficacy of the INTERCEPT™ Blood System
[amotosalen/ultraviolet A (UVA) light] to reduce the risk of Middle East respiratory syndrome …

Evaluation of MERS-CoV neutralizing antibodies in sera using live virus microneutralization assay

A Algaissi, AM Hashem - MERS Coronavirus: Methods and Protocols, 2020 - Springer
The microneutralization (MN) assay is a standard and important technique in virology,
immunology, and epidemiology. It is a highly specific and sensitive assay for evaluating …

Synthetic SARS-CoV-2 spike-based DNA vaccine elicits robust and long-lasting th1 humoral and cellular immunity in mice

SS Alamri, KA Alluhaybi, RY Alhabbab… - Frontiers in …, 2021 - frontiersin.org
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) calls for an urgent
development of effective and safe prophylactic and therapeutic measures. The spike (S) …

Inactivation of Middle East respiratory syndrome‐coronavirus in human plasma using amotosalen and ultraviolet A light

SI Hindawi, AM Hashem, GA Damanhouri… - …, 2018 - Wiley Online Library
BACKGROUND Middle East respiratory syndrome‐coronavirus (MERS‐CoV) is a novel
zoonotic pathogen. Although the potential for MERS‐CoV transmission through blood …

A novel bacterium-like particle vaccine displaying the MERS-CoV receptor-binding domain induces specific mucosal and systemic immune responses in mice

E Li, H Chi, P Huang, F Yan, Y Zhang, C Liu, Z Wang… - Viruses, 2019 - mdpi.com
Middle East respiratory syndrome coronavirus (MERS-CoV), a new coronavirus that has
been causing severe and fatal acute respiratory illnesses in humans since its outbreak in …

Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay

HA Alhadrami, AM Hassan, R Chinnappan… - Microchimica Acta, 2021 - Springer
The novel corona (SARS-CoV-2) virus causes a global pandemic, which motivates
researchers to develop reliable and effective methods for screening and detection of SARS …