Malaria, caused by Plasmodium species, remains a major global health concern, causing
millions of deaths annually. While the introduction of the RTS, S vaccine has shown promise …

Background: The long co-evolution of Homo sapiens and Plasmodium falciparum has
resulted in the selection of numerous human genetic variants that confer an advantage …

HIC-Vac is an international network of researchers dedicated to developing human infection
challenge studies to accelerate vaccine development against pathogens of high global …

Background Plasmodium falciparum variant surface antigens (VSAs) contribute to malaria
pathogenesis by mediating cytoadhesion of infected red blood cells to the microvasculature …

Controlled human malaria challenge studies in semi-immune volunteers provide an
unparalleled opportunity to robustly identify mechanistic correlates of protection. We …

Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also
known as human challenge studies and human infection studies, including Good …

Introduction: naturally acquired blood-stage malaria antibodies and malaria clinical data
have been reported to be useful in monitoring malaria change over time and as a marker of …

The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the
invasive merozoite stages of Plasmodium falciparum and has long been considered a key …

Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of
community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting …

The merozoite surface protein 1 (MSP1) is the most abundant protein on the surface of the
invasive merozoite stages of Plasmodium falciparum and has long been considered a key …