Tapinarof, a novel, first-in-class small-molecule topical therapeutic aryl hydrocarbon
receptor (AhR) modulating agent (TAMA), is in clinical development for the treatment of …

The aryl hydrocarbon receptor (AhR) has long been implicated in the induction of a battery
of genes involved in the metabolism of xenobiotics and endogenous compounds. AhR is a …

Neural control of the function of visceral organs is essential for homeostasis and health.
Intestinal peristalsis is critical for digestive physiology and host defence, and is often …

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness.
Analysis of disease tolerance pathways could provide new approaches for treating …

Intestine is always exposed to external environment and intestinal microorganism; thus it is
more sensitive to dysfunction and dysbiosis, leading to intestinal inflammation, such as …

Uremic toxins, such as indoxyl sulfate (IS) and p-cresol, or p-cresyl sulfate (PCS), are
markedly accumulated in the organs of chronic kidney disease (CKD) patients. These toxins …

The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …

The aryl hydrocarbon receptor (AHR), a member of the basic helix–loop–helix (bHLH) Per–
Arnt–Sim (PAS) family of transcription factors, plays important roles in regulating xenobiotic …

We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon
receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low …

The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification,
development, immune response, chronic kidney disease and other syndromes. It regulates …